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Page 1
Did you mean "neoplasms"[mh] AND gene AND (epo r epo r) (53 results)?
BCR-ABL1-like B-Acute Lymphoblastic Leukemia/Lymphoma: A Comprehensive Review.
Jain S, Abraham A. Jain S, et al. Arch Pathol Lab Med. 2020 Feb;144(2):150-155. doi: 10.5858/arpa.2019-0194-RA. Epub 2019 Oct 23. Arch Pathol Lab Med. 2020. PMID: 31644323 Free article. Review.
.-: In the 2016 update of the World Health Organization (WHO) classification of hematopoietic neoplasms, BCR-ABL1-like B-acute lymphoblastic leukemia/lymphoma (B-ALL) is added as a new provisional entity that lacks the BCR-ABL1 translocation but shows a pattern of gene exp …
.-: In the 2016 update of the World Health Organization (WHO) classification of hematopoietic neoplasms, BCR-ABL1-like B-acute lymphoblastic …
Philadelphia chromosome-like acute lymphoblastic leukemia.
Tasian SK, Loh ML, Hunger SP. Tasian SK, et al. Blood. 2017 Nov 9;130(19):2064-2072. doi: 10.1182/blood-2017-06-743252. Epub 2017 Oct 2. Blood. 2017. PMID: 28972016 Free PMC article. Review.
Philadelphia chromosome (Ph)-like acute lymphoblastic leukemia (ALL), also referred to as BCR-ABL1-like ALL, is a high-risk subset with a gene expression profile that shares significant overlap with that of Ph-positive (Ph(+)) ALL and is suggestive of activated kinase sign …
Philadelphia chromosome (Ph)-like acute lymphoblastic leukemia (ALL), also referred to as BCR-ABL1-like ALL, is a high-risk subset with a …
Targetable kinase-activating lesions in Ph-like acute lymphoblastic leukemia.
Roberts KG, Li Y, Payne-Turner D, Harvey RC, Yang YL, Pei D, McCastlain K, Ding L, Lu C, Song G, Ma J, Becksfort J, Rusch M, Chen SC, Easton J, Cheng J, Boggs K, Santiago-Morales N, Iacobucci I, Fulton RS, Wen J, Valentine M, Cheng C, Paugh SW, Devidas M, Chen IM, Reshmi S, Smith A, Hedlund E, Gupta P, Nagahawatte P, Wu G, Chen X, Yergeau D, Vadodaria B, Mulder H, Winick NJ, Larsen EC, Carroll WL, Heerema NA, Carroll AJ, Grayson G, Tasian SK, Moore AS, Keller F, Frei-Jones M, Whitlock JA, Raetz EA, White DL, Hughes TP, Guidry Auvil JM, Smith MA, Marcucci G, Bloomfield CD, Mrózek K, Kohlschmidt J, Stock W, Kornblau SM, Konopleva M, Paietta E, Pui CH, Jeha S, Relling MV, Evans WE, Gerhard DS, Gastier-Foster JM, Mardis E, Wilson RK, Loh ML, Downing JR, Hunger SP, Willman CL, Zhang J, Mullighan CG. Roberts KG, et al. N Engl J Med. 2014 Sep 11;371(11):1005-15. doi: 10.1056/NEJMoa1403088. N Engl J Med. 2014. PMID: 25207766 Free PMC article.
BACKGROUND: Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is characterized by a gene-expression profile similar to that of BCR-ABL1-positive ALL, alterations of lymphoid transcription factor genes, and a poor outcome. ...Cell lines and huma …
BACKGROUND: Philadelphia chromosome-like acute lymphoblastic leukemia (Ph-like ALL) is characterized by a gene-expression profile sim …
The novel GATA1-interacting protein HES6 is an essential transcriptional cofactor for human erythropoiesis.
Wang Z, Wang P, Zhang J, Gong H, Zhang X, Song J, Nie L, Peng Y, Li Y, Peng H, Cui Y, Li H, Hu B, Mi J, Liang L, Liu H, Zhang J, Ye M, Yazdanbakhsh K, Mohandas N, An X, Han X, Liu J. Wang Z, et al. Nucleic Acids Res. 2023 Jun 9;51(10):4774-4790. doi: 10.1093/nar/gkad167. Nucleic Acids Res. 2023. PMID: 36929421 Free PMC article.
Normal erythropoiesis requires the precise regulation of gene expression patterns, and transcription cofactors play a vital role in this process. Deregulation of cofactors has emerged as a key mechanism contributing to erythroid disorders. Through gene expression pr …
Normal erythropoiesis requires the precise regulation of gene expression patterns, and transcription cofactors play a vital role in t …
Targetable kinase gene fusions in high-risk B-ALL: a study from the Children's Oncology Group.
Reshmi SC, Harvey RC, Roberts KG, Stonerock E, Smith A, Jenkins H, Chen IM, Valentine M, Liu Y, Li Y, Shao Y, Easton J, Payne-Turner D, Gu Z, Tran TH, Nguyen JV, Devidas M, Dai Y, Heerema NA, Carroll AJ 3rd, Raetz EA, Borowitz MJ, Wood BL, Angiolillo AL, Burke MJ, Salzer WL, Zweidler-McKay PA, Rabin KR, Carroll WL, Zhang J, Loh ML, Mullighan CG, Willman CL, Gastier-Foster JM, Hunger SP. Reshmi SC, et al. Blood. 2017 Jun 22;129(25):3352-3361. doi: 10.1182/blood-2016-12-758979. Epub 2017 Apr 13. Blood. 2017. PMID: 28408464 Free PMC article. Clinical Trial.
Among the remaining patients, using reverse transcriptase polymerase chain reaction or transcriptome sequencing, we identified targetable ABL-class fusions (ABL1, ABL2, CSF1R, and PDGFRB) in 14.1%, EPOR rearrangements or JAK2 fusions in 8.8%, alterations activating other J …
Among the remaining patients, using reverse transcriptase polymerase chain reaction or transcriptome sequencing, we identified targetable AB …
Classification and genetics of pediatric B-other acute lymphoblastic leukemia by targeted RNA sequencing.
Migita NA, Jotta PY, Nascimento NPD, Vasconcelos VS, Centoducatte GL, Massirer KB, Azevedo AC, Brandalise SR, Yunes JA. Migita NA, et al. Blood Adv. 2023 Jul 11;7(13):2957-2971. doi: 10.1182/bloodadvances.2022009179. Blood Adv. 2023. PMID: 36848637 Free PMC article.
The classical TCF3-PBX1, ETV6-RUNX1, KMT2A-rearranged, and BCR-ABL1, and novel P2RY8-CRLF2, ABL-, JAK2-, ZNF384-, MEF2D-, and NUTM1-fusions were easily identified by fusion transcript analysis. IGH-CRLF2 and IGH-EPOR were found by abnormally high levels of expression of CR …
The classical TCF3-PBX1, ETV6-RUNX1, KMT2A-rearranged, and BCR-ABL1, and novel P2RY8-CRLF2, ABL-, JAK2-, ZNF384-, MEF2D-, and NUTM1-fusions …
Identification of bicalutamide resistance-related genes and prognosis prediction in patients with prostate cancer.
Li Y, Wang H, Pan Y, Wang S, Zhang Z, Zhou H, Xu M, Liu X. Li Y, et al. Front Endocrinol (Lausanne). 2023 Apr 18;14:1125299. doi: 10.3389/fendo.2023.1125299. eCollection 2023. Front Endocrinol (Lausanne). 2023. PMID: 37143720 Free PMC article.
Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses were performed, and hub genes were identified. ...Finally, we analyzed the tumor mutational heterogeneity and immune microenvironment in both groups. RESULTS: Two drug resistance gene m …
Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses were performed, and hub genes were identified. ...Fi …
Amplified EPOR/JAK2 Genes Define a Unique Subtype of Acute Erythroid Leukemia.
Takeda J, Yoshida K, Nakagawa MM, Nannya Y, Yoda A, Saiki R, Ochi Y, Zhao L, Okuda R, Qi X, Mori T, Kon A, Chiba K, Tanaka H, Shiraishi Y, Kuo MC, Kerr CM, Nagata Y, Morishita D, Hiramoto N, Hangaishi A, Nakazawa H, Ishiyama K, Miyano S, Chiba S, Miyazaki Y, Kitano T, Usuki K, Sezaki N, Tsurumi H, Miyawaki S, Maciejewski JP, Ishikawa T, Ohyashiki K, Ganser A, Heuser M, Thol F, Shih LY, Takaori-Kondo A, Makishima H, Ogawa S. Takeda J, et al. Blood Cancer Discov. 2022 Sep 6;3(5):410-427. doi: 10.1158/2643-3230.BCD-21-0192. Blood Cancer Discov. 2022. PMID: 35839275 Free PMC article.
Combining publicly available sequencing data, we found a high frequency of gains and amplifications involving EPOR/JAK2 in TP53-mutated cases, particularly those having >80% erythroblasts designated as pure erythroid leukemia (10/13). ...SIGNIFICANCE: This study reveals …
Combining publicly available sequencing data, we found a high frequency of gains and amplifications involving EPOR/JAK2 in TP53-mutat …
Erythropoietin, Stem Cell Factor, and Cancer Cell Migration.
Vazquez-Mellado MJ, Monjaras-Embriz V, Rocha-Zavaleta L. Vazquez-Mellado MJ, et al. Vitam Horm. 2017;105:273-296. doi: 10.1016/bs.vh.2017.02.008. Epub 2017 Apr 17. Vitam Horm. 2017. PMID: 28629522 Review.
Erythropoietin (Epo) is a glycoprotein hormone that regulates erythropoiesis and is also known to be a potent chemotactic agent that induces cell migration by binding to its receptor (EpoR). Expression of EpoR has been documented in tumor cells, and the potential of …
Erythropoietin (Epo) is a glycoprotein hormone that regulates erythropoiesis and is also known to be a potent chemotactic agent that induces …
[EPO and EPOR Expression in Patients with Acute Leukemia and Its Clinical Significance].
Tian RM, Huang CS, Su Q, Shi L, Luo X, Chen Y. Tian RM, et al. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2019 Aug;27(4):1026-1032. doi: 10.19746/j.cnki.issn.1009-2137.2019.04.006. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2019. PMID: 31418352 Chinese.
METHODS: The levels of EPO and EPOR in plasma were determined by ELISA kit. mRNA expression levels of EPO and EPOR were determined by RT-RCR. ...CONCLUSION: The expressions of EPO and EPOR is higher in ALL and AML patients. The expression levels of EPO and …
METHODS: The levels of EPO and EPOR in plasma were determined by ELISA kit. mRNA expression levels of EPO and EPOR were determ …
223 results